Abstract
The Coronavirus (SARS-CoV-2) is one of the deadliest viruses of current era and is identified as the causative agent of novel coronavirus disease-2019 (COVID-19). This disease stances a severe risk to mankind due to its unexplored pathologies. It was declared as a COVID-19 pandemic by the world health organization. This outbreak has challenged the public health concerns at large, killing the most vulnerable person, causing generalized panic and become a top debate among scientists, clinicians, physicians, pathologists, economists, athletes and politicians. Anti-viral vaccines and target drugs to treat this virus are unavailable due to its diverse genetic instability. Currently, its prevention, control and treatment are questionable as no proven remedies have been effective for its cure so far. From a research assessment, many number of drugs or medicines are being manufactured and tested at fast pace, goals and objectives are being celebrated on daily basis, and also many drugs are be subjected to clinical tests. Scientists are interested about how to provide the better care to everyone before a vaccine can be made available to common community. To stop COVID-19, effective solutions (i.e., personal protection elements, vaccines, drugs, etc.) are needed urgently. Red bells are ringing but there is no way out. Current review focuses on the ongoing regimes and therapeutic interventions for better combat with COVID-19.
Highlights
The global challenge of COVID-19 started in late December, particular with rapid increase of critically ill patients having symptoms of pneumonia [1]
Neither anti-viral therapeutic agents nor any effective vaccines have been approved for the treatment of any human CoV disease or COVID19 till date
angiotensin exchanging enzyme-2 receptor (ACE2) protein attached to a human IgG Fc (ACE2-Fc) domain of SARS-CoV-2 patients can have the advantages of a conventional counteracting antibody that might be effective for the therapy of disease
Summary
Muhammad Yasir Waqas a, Muhammad Arshad Javid b, Muhammad Mudasser Nazir c, Azhar Aslamd, Sheraz Ahmed Bhatti c, Asim Faraz e, Qaiser Akram f, Nasir Niaz g, Muhammad Farrukh Nisar a, Tanveer Ahmed h, Muhammad Asif i, Muhammad Haseeb Khaliq j, Shaukat Munawar k, Zahid Manzoor k and Qurban Ali l*. A Department of Physiology and Biochemistry, Cholistan University of Veterinary and Animal Sciences Bahawalpur 63100, Pakistan. B Department of Biosciences, Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. C Department of Pathobiology, Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. E Department of Livestock and Poultry Production, Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. H Department of Clinical Sciences, Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. J Department of Anatomy and Histology, Cholistan University of Veterinary & Animal Sciences, Bahawalpur 63100, Pakistan. K Department of Pharmacology & Toxicology, Cholistan University of Veterinary & Animal Sciences, Bahawalpur 63100, Pakistan. All authors read and approved the final manuscript. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/73393
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