A review on electrophilic thiocyanation of aromatic and heteroaromatic compounds

Abstract

The electrophilic thiocyanation of aromatic and heteroaromatic compounds such as oxindoles, indoles, isatins, indolines, quinolines, and pyrroles and also N-activeted arenes such as anilines, N,N-dialkylamines, and arylamines with thiocyanation agent/oxidant in the presence of acidic catalyst are represents an essential direct procedure to the synthesis of aryl and heteroaryl thiocyanates derivatives. Various thiocyanation agents such as NH4SCN, KSCN and some catalysts especially ILs with thiocyanation agent are an important reagent for the production of such class of thiocyanate intermediates. In the decade past, the considerable advances have been made for the direct thiocyanation of aromatic, heteroaromatic and N-activeted arenes compounds with high selectivity and yield. In this review, we have classified a variety of procedures the last nine years based on various catalysts for the preparation of aryl and heteroaryl thiocyanates derivatives since 2012 until now.