Abstract
Diabetes has become considered one of the most common health-care crisis of the 21st century. Diabetes increases the risk of various microvascular and macrovascular diseases. Diabetic neuropathy is one of the microvascular complications that can affect as many as 50% of patients with diabetes. It is generally agreed that the toxic consequences of hyperglycemia play a significant part in the emergence of this problem, but several other hypothesis also have been proposed. Diabetes can lead to variety of neuropathic problems, both acute and chronic, that can impact the peripheral nerve at every level from the root to the distal axon. Major international clinical recommendations for the therapy of Diabetic peripheral neuropathy [DPN] offer many symptomatic therapies. Tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, and anticonvulsants are among the first-line treatments. Opioids and topical medications like capsaicin cream and lidocaine patches are among the further treatments. The main focus of this review is recommendations for the management of DPN. Keywords: Diabetes, DPN, Hyperglycemia, Antidepressants, Anticonvulsants
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