Abstract
The modern drug delivery system of hydrophobic drugs presents a main challenge because of the poor aqueous solubility of such compounds. Self emulsifying drug delivery systems (SEDDS) are usually used to enhance the bioavailability of hydrophobic drugs. SEDDS can be administered orally in soft or hard gelatin capsules and form fine relatively stable oil in water (o/w) emulsions upon aqueous dilution due to the gentle agitation of the gastrointestinal fluids. From time to time so many workers have claimed different rational applications of Self-emulsifying formulation for increcing bioavailability and site-specific targeting of highly lipophilic drugs. Significant improvement in the oral bioavailability of these drug compounds has been demonstrated for each case. The fact that almost 40% of the new drug compounds are hydrophobic in nature implies that studies with SEDDS will continue, and more drug compounds formulated as SEDDS will reach the pharmaceutical market in the future. The present article gives an overview of the Composition, mechanism, advantages, disadvantages, characterization, recent advancements, patents related information of SEEDS and commercial products approved for oral transmucosal administration.
Highlights
Oral intake is the most convenient and commonly employed route of drug delivery by the patients as well as the manufacturers for the treatment of diseases due to its ease of administration, high patient compliance, cost-effectiveness, least sterility constraints and flexibility in the design of dosage form
Dioctyl sodium sulfosuccinate has proved to increase the intestinal absorption of many drugs[76,77] While the number of publications on the possible application of aerosol OT micro emulsions for topical drug delivery is already extensive, aerosol OT applicability for oral micro emulsion drug delivery still needs to be studied[78,79] Recently, a patent cooperation treaty (PCT) provided a stable, selfemulsifying water/oil micro emulsion in which the surfactant with high Hydrophilic Lipophilic Balance (HLB) comprises a medium-chain alkyl/dialkyl sulfate, sulfonate, or sulfosuccinate salt dissolved in a polyhydric alcohol to improve the delivery characteristics of a therapeutic peptide drug[80]
The oral delivery of hydrophobic drugs can be made possible by Self emulsifying drug delivery systems (SEDDS), which have been shown to substantially enhance oral bioavailability
Summary
Oral intake is the most convenient and commonly employed route of drug delivery by the patients as well as the manufacturers for the treatment of diseases due to its ease of administration, high patient compliance, cost-effectiveness, least sterility constraints and flexibility in the design of dosage form. Self emulsifying drug delivery systems (SEDDS): The major technique for enhancing bio-availability is SEDDS, which uses lipophilic, pre-concentrated solutions of the API and excipients (a liquid carrier, a surfactant and a cosurfactant). They emulsify spontaneously when, come in contact with fluids of GIT to form oil-in-water emulsions or microemulsions under mild agitation[22]. Drug incorporation into SEDDS: Drugs with low aqueous solubility present a major challenge during formulation as their high hydrophobicity prevents them from being dissolved in most approved solvents. Colloidal silicon dioxide (Aerosil 200) was selected as a gelling agent for the oil-based systems, which served the dual purpose of reducing the amount of required solidifying excipeints and aiding in slowing down of the drug release[68]
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