A Review on Crisis of Antibiotic Resistance

Abstract

The current challenges and crisis related to antibiotic use and its resistance are unique and differ from the past challenges, as there is a lot of novel pathogens involved in the emergence of antibiotics resistance. Antibiotic resistance has become a major concern and challenge, hindering the usage of antibiotics. Crisis of antibiotic resistance is the increasing global incidence of infectious diseases affecting human population making it untreatable with any known antibiotic or antimicrobial agent. Newer resistance mechanisms are emerging and spreading globally thereby, imposing a major threat to the treatment of common infectious diseases. This has consequently led to an increase in the morbidity and mortality rates and thereby the rise in cost of the treatment as well. The process of antibiotic resistance has become an evolutionary response due to factors like widespread, extensive, and unnecessary use of antibiotics and unavailability of newer drugs attributable to exigent regulatory requirements. The situation in developing countries is expected to worsen unless governments become more stable, major advances occur in standards of living, preventive measures and in providing adequate medical care. Comprehensive and coordinated efforts are required to minimize the pace of resistance by implement new policies, researches and pursue steps to manage crisis. Keywords: antibiotics, resistance, crisis micro-organisms.