A review on co-processed excipients used in direct compression of tablet dosage form

Abstract

Co-processed excipients may enhance functionality and reduce drawbacks of traditional excipients for the manufacture of tablets on a commercial scale. The following study aimed to characterize a range of co-processed excipients that may prove suitable for dispersible tablet formulations prepared by direct compression. The dosage form that is used the most is tablets. Their accessibility, simplicity of administration, consistency, and affordability are advantages. Direct compression is the most straightforward method for making tablets, despite the fact that it comes with several challenges, including those connected to the homogeneity and mass variation of the content, disintegration, dissolution, and the radial hardness of the tablets. In today's world, "co-processed excipients," which include frequently processed mixtures of fillers, binders, disintegrants, lubricants, and other excipients, are becoming more popular. Spray drying, fluid bed granulation, wet granulation, melt granulation, dry granulation, and co-crystallization are used to create these mixes. This review article lists technologies, co-processed excipients that are commercially available, and excipients that are typically utilized to make them.