A REVIEW ON CIPROFLOXACIN: DOSAGE FORM PERSPECTIVE

M Vidyavathi,G Srividya

doi:10.22159/ijap.2018v10i4.25315

M Vidyavathi, G Srividya

Open Access

https://doi.org/10.22159/ijap.2018v10i4.25315

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Abstract

Ciprofloxacin (CF) is one of the topmost selling antibiotics and it is available at a cheap cost which is used to treat many bacterial infections. Many research scientists are working on this drug for various applications on different drug delivery systems. The main objective of this paper is to enlighten about the details of pure drug CF and its delivery systems along with current research on this drug. This review focused on history, pharmacokinetics, mechanism of action, types of dosage form available in the market with their cost, current research going on this drug with their applications and methods development for estimation of CF. It also highlighted the possible interactions and adverse drug reactions of CF and patents available. The present review revealed that the only analytical method for estimation of CF was developed in the first decade, few drug delivery systems (DDS) of CF were developed in the second decade and more research work on the development of novel DDS of CF founded in the last decade.

Highlights

Ciprofloxacin (CF) is an antibiotic which is available at a cheap cost [1] and used to treat many bacterial infections [2]
Several analytical methods for the quantitative determination of CF in pharmaceutical formulations were developed like electrophoresis, UV spectrophotometry, titration, and HighPerformance Liquid Chromatography (HPLC)
The present review revealed that analytical methods to determine CF was developed for its pharmacokinetic studies in the first decade of the selected review period (1985-1995)

Summary

Introduction

Ciprofloxacin (CF) is an antibiotic which is available at a cheap cost [1] and used to treat many bacterial infections [2]. It belongs to fluoroquinolones category and is a broad spectrum second generation antibacterial agent [3]. It is mostly used to treat gram negative bacterial infections, urinary tract infections, skin, ophthalmic, respiratory, bone and joint, intraabdominal infections bacterial diarrheal infections [4] and periodontal pathogens [5]. It is not effective against viral diseases. It is one of the topmost selling antibiotics [1] and numbers of researchers are working with this drug for different applications or improvements in its applications

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Conclusion