A REVIEW ON BIOLOGICAL ACTIVITY OF 1, 3-DIAZOLE DERIVATIVES

Abstract

1,3-diazole is also known as imidazole.1, 3-diazole is amphoteric in nature i.e. it shows both acidic and basic properties 1, 3-diazole is a five-member heterocyclic aromatic compound that possesses two nitrogen, three carbon, four hydrogen atom and two double bond. It has two nitrogen atom are present; both nitrogen atom are sp2 hybridized. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. The derivatives of 1,3-diazole show different biological activities such as. Anti-inflammatory, antimicrobial, analgesic and anti-tubercular activities, etc. as reported in the literature. There are different examples of commercially available drugs in the market which contains a 1,3-diazole ring, such as Miconazole, Clotrimazole, Econazole, Enilconazole, Sulconazole etc This present review summarized some pharmacological activities and various kinds of synthetic routes for 1, 3-diazoleand their derived products.