Abstract
Dihydropyrimidinones and thiones are a significant class of organic as well as heterocyclic compounds synthesized by cyclo condensation reaction, called Biginelli reaction that was reported for the first time by Italian chemist Pietro Biginelli in 1893. The synthesis of dihydropyrimidinones and thiones involve one pot multicomponent reaction (MCR) of various aldehydes, β- ketoester and urea or thiourea. Now, the dihydropyrimidinones and thiones have emerged as one of the most advantaged medicinal pharmacophores as they appear as an important structural part in many naturally occurring and synthetically prepared medicinal drugs. It possesses wide spectrum of biological activities like antitubercular, Anti-malarial, anticancer, anti-HIV activity, analgesic, antiepileptic, CNS activity, anti-inflammatory, calcium and potassium channel blocker [2], antihypertensive agents [3], α-la-antagonist [4], antioxidants [6] and neuropeptide Y (NPY) antagonists.[7]
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