Abstract
Tenofovir Disoproxil Fumarate and Emtricitabine are very effectively used in the prevention of HIV-1 infections. They are generally administered as tablets. These are Nucleotide Reverse Transcriptase Inhibitors (NtRTIs), an acyclic nucleoside phosphonate (nucleotide) analog of adenosine 5′-monophosphate. Emtricitabine and Tenofovir disoproxil fumarate reveals equally prevention of the enzyme that is HIV-1 reverse transcriptase. For determination of Tenofovir disoproxil fumarate and Emtricitabine in bulk and pharmaceutical dosage form, several analytical methods including UV, HPLC, UPLC and HPTLC techniques are reported in literature. For qualitative and quantitative estimation of Tenofovir disoproxil fumarate and Emtricitabine these analytical methods can be used and also for the related degradants in bulk formulations and biological fluid. The present paper illustrates the review on analytical methods which involves the estimation of the antiviral drugs.
 Keywords: Emtricitabine, Tenofovir disoproxil fumarate, UV Spectroscopy, RP-HPLC, UPLC, HPTLC.
Highlights
The human immunodeficiency viruses (HIV) is grouped to the genus Lentivirus within the family of Retroviridae, initiates the HIV infection and the over time Acquired Immunodeficiency Syndrome (AIDS)
Combination of the Tenofovir disoproxil fumarate and Emtricitabine is marketed as a tablet (TENVIREM) and it constitutes the 300 mg of Tenofovir disoproxil fumarate and 200 mg of Emtricitabine
This review portrays that the accounted Spectroscopic and Chromatographic methods developed and validated for estimation of Tenofovir disoproxil fumarate and Emtricitabine
Summary
The human immunodeficiency viruses (HIV) is grouped to the genus Lentivirus within the family of Retroviridae, initiates the HIV infection and the over time Acquired Immunodeficiency Syndrome (AIDS). Molecular formula is C23H34N5O14P and the molecular weight is 635.52gm/mol It is a nucleotide reverse transcriptase inhibitor (NtRTIs), selectively inhibits the viral reverse transcriptase enzyme crucial for the viral production of Human Immunodeficiency Virus (HIV) infected individuals. This drug prevents viral DNA chain elongation through inhibition of enzymes necessary for host cell infection viral replication in HIV-1 and Hepatitis B infections. Combination of the Tenofovir disoproxil fumarate and Emtricitabine is marketed as a tablet (TENVIREM) and it constitutes the 300 mg of Tenofovir disoproxil fumarate and 200 mg of Emtricitabine It is an intended for the treatment of the HIV-1 virus and Hepatitis B infections.
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