Abstract
Apremilast is approved by USFDA in 2014. It is used in treatment of psoriatic arthritis and other conditions like atopic dermatitis and plaque psoriasis. It is act as an anti-inflammatory agent. It is phthalimide derivative and belongs to class 4 category of BCS system. It is a phosphodiesterase-4 (PDE-4) inhibitor. Analytical methods plays an important role to describe physico-chemical properties of drug. Due to low solubility and low permeability analytical method development and formulation becomes challenging. Till date, there are no standard test methods available to analyze Apremilast. So, a review of the analytical methods for apremilast is carried out. Here we discussed latest analytical methods for estimation of apremilast in bulk, Pharmaceuticals dosage form and in biological samples. In that we study methods like HPLC, UV-Visible spectroscopy, HPTLC, UPLC and mostly used hyphenated technique LC-MS. This review will be helpful for the researcher who is working on apremilast.
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