Abstract
A simple, economical and rapid by UV detector and PDA Detector was used for Estimation of Trandolapril and Verapamil in combination and other drugs in various Pharmaceutical formulation. Calcium channel blockers(CCBs) and angiotensin- converting enzyme (ACE) inhibitors has been developed and fully validated by High performance liquid Chromatographic Methods. Calcium channel blockers (CCBs) or Calcium antagonists are among the most widely used drugs in cardiovascular medicine and hypertension also in angina. CCBs promote vasodilator activity by reducing calcium influx into vascular smooth muscle cells by interfering with calcium channels in the cell membrane. Trandolapril is a potent nonsulfhydryl and dicarboxyl containing Angiotensin converting inhibitor (ACE). Trandolapril used to treatment of hypertension appears to result the inhibition of tissue ACE activity and to improve survival myocardial infarction thereby reduce angiotensin II formation.
 It includes drugs like Trandolapril, Norverapamil, Nifedipine, Verapamil. This Review enlists different method Developed, Validated and determination of Calcium channel blockers and angiotensin- converting enzyme inhibitors Like, RP-HPLC, LC-MS/MS and HPLC UV- Spectophotometric method. This method was also validated for various validation terms indicates that precise, accurate, linearly, and limit of Detection and limit of Quantitation as per ICH guidelines.
 Keywords: HPLC Chromatography, Calcium Channel blocker, angiotensin- converting enzyme (ACE) inhibitors, Hypertension, Validation etc.
Highlights
Trandolapril is a colorless and crystalline solid soluble in chloroform, methanol and dichloromethane, odourless powder which melts in the range of 125-130o C
Monoester prodrug of a Trandolapril was hydrolysed by esterases to its active dicarboxylic acid metabolite in syntehsis converted to the Trandolaprilat [9]
Verapamil is solid freely soluble in water, chloroform and methanol which melts range of 138-140 °C
Summary
Trandolapril is a colorless and crystalline solid soluble in chloroform, methanol and dichloromethane, odourless powder which melts in the range of 125-130o C. Monoester prodrug of a Trandolapril was hydrolysed by esterases to its active dicarboxylic acid metabolite in syntehsis converted to the Trandolaprilat [9]. Amphoteric compounds like trandolapril is a potent nonsulfhydryl and dicarboxyl containing Angiotensin converting inhibitor(ACE). Trandolapril used to treatment of hypertension appears to result the inhibition of tissue ACE activity and to improve survival myocardial infarction thereby reduce angiotensin II formation, and treatment for congestive heartfailure, decreases the rate of aldosterone secretion, and incease plasma renin. Calcium channel blockers (CCBs) are a structurally and functionally heterogeneous group of medications that are used widely to control blood pressure and manage symptoms of angina. Reported methods are categorized depending on the following considerations: Analyzed by Single component with other class drugs for combination with Calcium channel blocker with angiotensin- converting enzyme (ACE) inhibitors by UV-Spectroscopy methods and Chromatographic method
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
