A review of TTS – development, types and preparations

Abstract

Transdermal Therapeutic Systems (TTS) are elastic multi-layer patches applied to the skin in order to deliver active substances into the bloodstream. One advantage of a transdermal drug delivery route over other types of medication delivery is that the patch provides a noninvasive therapy, longer duration of drug activity, and improves most of bioavailability. TTS consist of a backing layer, a drug, an adhesive, and a release liner. TTS can be divided into five basic types of systems: reservoir, matrix, microreservoir, single-layer drug in adhesive, and multi-layer drug in adhesive. In order to improve the penetration of drugs through the skin, passive and active methods are used. The researchers are constantly developing new methods of improving the delivery of drugs applied by transdermal route.