A Review of the Sub-Classification of Lymph Node Biopsies Reported as Reactive Lymphadenitis at Kenyatta National Hospital, Kenya

Chepkorir Cynthia Chemonges,Joseph Ndungu Rugumu,Nyagol Joshua

doi:10.23937/2469-5807/1510120

Chepkorir Cynthia Chemonges, Joseph Ndungu Rugumu + Show 1 more

Open Access

https://doi.org/10.23937/2469-5807/1510120

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Abstract

Lymphadenopathy is common in both adult and paediatric patients in Kenya. It has a broad differential diagnosis, the most common being non-specific reactive lymphoid hyperplasia. Prevalence and morbidity of malignancies in early stages, such as micro lymphoma in reactive lymphadenitis remains poorly investigated.

Highlights

Non-specific reactive hyperplasia, a benign reversible enlargement of the lymph node, is the leading cause of lymphadenopathy
This study evaluated the histopathologic patterns of lymph node biopsies reported as reactive lymphadenitis at Kenyatta National Hospital between 2013-2019
Sub-classifications of reactive lymphadenitis may help in diagnosis of underlying pathologic conditions

Summary

Introduction

Non-specific reactive hyperplasia, a benign reversible enlargement of the lymph node, is the leading cause of lymphadenopathy. When lymphoma features as differential diagnosis in lymphadenopathy, there has been only paucity of reported data on the prevalence of micro lymphoma, when ancillary testing is not utilized alongside morphological evaluation [6-8]. In such instances, lymphadenopathies have often been diagnosed as reactive lymphadenitis, but later found to be of specific pathologic processes [9,10]. Lymphadenopathy is common in both adult and paediatric patients in Kenya It has a broad differential diagnosis, the most common being non-specific reactive lymphoid hyperplasia. Prevalence and morbidity of malignancies in early stages, such as micro lymphoma in reactive lymphadenitis remains poorly investigated

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Conclusion