Abstract
It is established that normal calcium and vitamin D concentrations are maintained in the body through parathyroid hormone (PTH), a signaling molecule secreted from parathyroid glands. A massive role is played by PTH in increasing calcium levels when they are extremely low in the body through different mechanisms. The dysregulation of this hormone is due to either over functioning of the gland (hyperparathyroidism) or compromised functioning in hypoparathyroidism. A detailed review was done to identify if any changes are happening in the cerebrospinal fluid (CSF) due to any pathology causing the parathormone to be dysregulated enough to, in turn, cause any further pathology in the nervous system. This may then lead to various disabling neuropsychiatric features. The calcium and vitamin D abnormalities are both directly and indirectly connected to psychiatric features like delusions, schizophrenia, disabled cognition, psychosis, coma, mania, and depression of all kinds.Moreover, their irregularities are also linked to Alzheimer's. During these manifestations, the CSF is altered concentration-wise, where elevated calcium levels inside are observed during different studies. Despite PTH's indirect connection to the CSF modifications, their association hasn't been potently proven yet, considering more observational studies should be conducted in humans and for a more extended period, along with bigger and greater numbers of CSF samples. Suppose there is a possibility of the link of CSF alterations to PTH. In that case, we can consider a pronounced increase of CSF calcium or PTH as a risk factor for debilitating neuropsychiatric diseases. In this review, the possible correlation of CSF and PTH has been discussed.
Highlights
BackgroundIf you skew the endocrine system, you lose the pathways to self; when the endocrine pattern changes, it alters the way you think and feel
We aim to explore the possibility of any linkage between the cerebrospinal fluid (CSF) alterations due to any pathology related to the parathyroid gland, which can, in turn, serve as a cause for neuropsychological repercussions
Our review pointed towards the parathormone's concentration and its regulation by the parathyroid gland that can disrupt the neurological and psychiatric system and function by causing any alterations in the CSF
Summary
If you skew the endocrine system, you lose the pathways to self; when the endocrine pattern changes, it alters the way you think and feel. Six months post-surgery to evaluate the difference in psychopathological, neuropsychiatric, and cognitive disabilities after the surgery and due to proper observations being carried out during the study and evidence collected, parathyroidectomy was suggested to ease the symptoms in all diagnosed patients even if asymptomatic with slightly impaired cognition [22] Another case-control research was done to see whether the removal of the parathyroid gland can ameliorate the quality of life by easing the neuropsychological symptoms. The severity of the symptoms had dropped down markedly [23] To prove this strongly, another case-control study that aimed to analyze Calcidiol (25[OHD) levels in patients affecting their mental health demonstrated that the risk of vitamin D deficiency is a possible risk factor in recurrent depression without it associating with the management of depression in any way [24]. The various qualities, objectives, types, and conclusions of studies explained in the above passage have been summarized in Table 1 [1,2,3,4,8,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24]
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