Abstract
The HUGO Gene Nomenclature Committee (HGNC) approves unique gene symbols and names for human loci. As well as naming genomic loci, we manually curate genes into family sets based on shared characteristics such as function, homology or phenotype. Each HGNC gene family has its own dedicated gene family report on our website, www.genenames.org. We have recently redesigned these reports to support the visualisation and browsing of complex relationships between families and to provide extra curated information such as family descriptions, protein domain graphics and gene family aliases. Here, we review how our gene families are curated and explain how to view, search and download the gene family data.
Highlights
Grouping human genes together into gene families helps the scientific and clinical community to quickly find related sets of genes in order to plan studies and interpret existing data
There are many resources available that group genes together based on specific product functions such as Carbohydrate-Active enZYmes Database (CAZy) [1], IUPHAR/BPS Guide to Pharmacology [2] and the Nuclear Receptor Resource [3]
There are ontologies that group human genes together based on function, phenotype or sequence, e.g. Gene Ontology [8], the Phenotype Ontology [9] and the Sequence Ontology [10]
Summary
Grouping human genes together into gene families helps the scientific and clinical community to quickly find related sets of genes in order to plan studies and interpret existing data. The HUGO Gene Nomenclature Committee (HGNC) [11] is the only manual curation team that groups human genes into families based on a variety of characteristics, whilst providing further links to other resources for each family member. We provide visual maps showing these gene family hierarchies and links between pages so that the user may navigate between different levels.
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