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Abstract
Scrub typhus is a serious public health problem in the Asia-Pacific area. It threatens one billion people globally, and causes illness in one million people each year. Caused by Orientia tsutsugamushi, scrub typhus can result in severe multiorgan failure with a case fatality rate up to 70% without appropriate treatment. The antigenic heterogeneity of O. tsutsugamushi precludes generic immunity and allows reinfection. As a neglected disease, there is still a large gap in our knowledge of the disease, as evidenced by the sporadic epidemiologic data and other related public health information regarding scrub typhus in its endemic areas. Our objective is to provide a systematic analysis of current epidemiology, prevention and control of scrub typhus in its long-standing endemic areas and recently recognized foci of infection.
Highlights
Scrub typhus is a serious public health problem in the Asia-Pacific area including, but not limited to, Korea, Japan, China, Taiwan, India, Indonesia, Thailand, Sri Lanka, and the Philippines (Fig 1)
We here provide a comprehensive review of the epidemiology, prevention and control of scrub typhus
We provide here a systematic analysis of current epidemiology, prevention and control of scrub typhus in the endemic areas as well as among travelers from the rest of the world
Summary
Scrub typhus is a serious public health problem in the Asia-Pacific area including, but not limited to, Korea, Japan, China, Taiwan, India, Indonesia, Thailand, Sri Lanka, and the Philippines (Fig 1). It threatens one billion people globally, and causes illness in one million people each year [1]. Known as tsutsugamushi disease, is caused by the arthropodborne gram-negative obligately intracellular bacillus Orientia tsutsugamushi [2,3,4].
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