Abstract
Optical coherence tomography (OCT) has recently attracted a lot of interest in the pharmaceutical manufacturing industry as a fast, contactless and non-destructive modality for quantifying thin film coatings on pharmaceutical dosage forms, which cannot be resolved easily with other techniques. In this topical review, we present an overview of the research that has been performed to date, highlighting key differences between systems and outlining major challenges ahead.
Highlights
In pharmaceutical manufacturing, film coating on solid oral dosage forms is performed as part of the secondary manufacturing
Optical coherence tomography (OCT) is based on low-coherence interferometry, which operates in accordance with the principle interference between two optical beams when the optical path difference (OPD) is within the coherence length of the light source
There are three types of OCT modalities that have been applied in pharmaceutical film coating imaging: time-domain full-field OCT (FF-OCT), spectral-domain (SD-OCT) and swept-source
Summary
Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool L69 3GJ, UK; EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation, University of Strathclyde, 99 George Street, Glasgow G1 1RD, UK Received: 30 October 2018; Accepted: 11 December 2018; Published: 19 December 2018
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