Abstract
Chalcones are the principal precursors for the biosynthesis of flavonoids and isoflavonoids. A three-carbon α, β-unsaturated carbonyl system constitutes chalcones. Chalcones are the condensation products of an aromatic aldehyde with acetophenones in attendance of catalyst. A lot of methods and schemes have been reported for the synthesis of these compounds. Amongst all, Aldol condensation and Claisen-Schmidt condensation reactions are the most cited synthetic protocols in literature, nevertheless, Suzuki reaction, Witting reaction, and Photo-Fries rearrangement have also been utilized as synthetic protocols towards the chalcone framework. Several catalysts have been developed in the synthesis of the chalcone framework among which SOCl 2 natural phosphate, lithium nitrate, amino grafted zeolites, zinc oxide, water, K 2 CO 3 , PEG400, silica sulfuric acid, ZrCl 4, and ionic liquid are the most cited ones. The development of better synthetic techniques for the synthesis of α, β- unsaturated carbonyl compounds is still remaining high demand. Keywords: Chalcones, Aldol condensation, Claisen-Schmidt condensation, Suzuki reaction, Witting reaction, Photo-Fries rearrangement DOI: 10.7176/CMR/14-3-01 Publication date: August 31 st 2022
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