A Review of Some Treatments for Oral Mucositis Induced by Using 5-Fluorouracil

Abstract

Oral mucositis (OM) remain the principal complication and costly side effect of cancer chemotherapy. It is creating progressively important contribution to mortality rate as the clinical manifestation ranging from moderate including pain and impairs food and drink ingestion to sever mucosal lesion which developed to life threading due to intense immune suppression. 5-Fluorouracil (5-FU) is a pyrimidine analogue which considered as a vital treatment for diversified shapes of solid tumors for over 40 years. Intravenous (IV) route of 5-Fluorouracil medication treating are commonly used. Experimental studies had demonstrated that the uracil was necessary for sustaining nucleic acid synthesis required for tumor growth, this led to hypothesis the 5-flurauracil might interfere with nucleic acid synthesis and slow tumor growth. Use of 5-FU drug is one of the most common causes of OM. Our review demonstrates and cooperate the drugs and beside diminish riskiness of chemotherapy 5-FU as a causes of OM in experimental animal.