Abstract
One way to study the specific response of the non-visual melanopsin photoreceptors of the human eye is to silence the response of cones and rods. Melanopsin photoreceptors (ipRGC), highlighted in the early 2000s, are intimately linked to the circadian rhythm and therefore to our sleep and wakefulness. Rest and sleep regulation, health and cognitive functions are all linked to ipRGC and play an important role in work and human relationships. Thus, we believe that the study of ipRGC responses is important.We searched and reviewed scientific articles describing instrumentation dedicated to these studies. PubMed lists more than 90,000 articles created since the year 2000 that contain the word circadian but only 252 with silent substitution. In relation to melanopsin, we found 39 relevant articles from which only 11 give a device description for humans, which is incomplete in most cases. We did not find any consensus for light intensity description, melanopsin contrast, sequences of melanopsin light stimulation and optical setup to expose the retina to the light.
Highlights
Inside the eye, light is captured and interpreted by the rod and cone photoreceptive system for image perception
We looked at the scientific publications using the silent substitution method for studying ipRGC
We first restricted our search to PubMed, we searched on the International Society for Optics and Photonics (SPIE) and Institute of Electrical and Electronics Engineers (IEEE) databases
Summary
Light is captured and interpreted by the rod and cone photoreceptive system for image perception. At the beginning of the 21st century, a non-visual photoreceptive system was identified in mammalian eyes [1,2]. Its base unit is an intrinsically photosensitive retinal ganglion cell that uses the photopigment melanopsin (ipRGC, pRGC, mRGC or melanopsin). It was later discovered that it plays a role in spatial vision [3,4]. The temporal properties of ipRGC signaling are distinct from those of rods and cones, including longer latency and sustained signaling after light offset [5,6]. The sensitivity of melanopsin overlaps those of S, M and L cones and its peak lies at 490 nm [7] (see Figure 1)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
