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Abstract
Poor medication adherence is a major problem in chronic diseases such as osteoporosis that may partially be due to unaddressed patient values and preferences. Data on patient preferences could help clinicians to improve medication adherence and could also be useful in policy decisions and guideline development. This paper aims to identify literature reporting on the preferences of patients for osteoporosis drug medications. Several methods have been used to elicit patient preferences for medications and their characteristics including qualitative research, survey with ranking/rating exercises, discrete-choice experiments and clinical studies (crossover designs, open-label study). All these studies revealed that osteoporotic patients have preferences for medications and their attributes, in particular for less-frequent dosing regimens. Interestingly, variations in the preferences of patients were observed in most studies, suggesting the importance to take into account individual preference in decision-making to improve osteoporosis care.
Highlights
Osteoporosis represents an increasing public health problem, especially in the Western world
Poor adherence to therapy may partially be due to unaddressed patient values and preferences [5]
Understanding what patients prefer and involving them in clinical decision-making could lead to improved satisfaction with therapy and medication adherence [6]
Summary
Osteoporosis represents an increasing public health problem, especially in the Western world. For the year 2010, it was estimated that about 27.5 million of people from the European Union have osteoporosis [1], resulting in approximately 3.5 million new fractures. Despite the fact that several drugs have demonstrated to be safe and effective in reducing the risk of fractures [2], adherence to medications remains poor and suboptimal [3], with substantial clinical and economic implications [4]. Understanding what patients prefer and involving them in clinical decision-making could lead to improved satisfaction with therapy and medication adherence [6]. Patient perceptions and preferences with osteoporosis medications were shown to impact adherence behaviour [7] and discontinuation rates [8]. In recent years, there has been a growing interest in studies to elicit preferences for healthcare interventions. There are different ways to elicit patient preferences including qualitative research, survey with ranking/ rating exercises, discrete-choice experiments and clinical studies (such as crossover or open-label study)
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