A review of new hormonal therapies for prostate cancer in black men: is there enough data?

Matthias E Meunier,Thierry Lebret,Laurent Brureau,Pascal Blanchet,Yann Neuzillet

doi:10.1186/s12885-020-07780-7

Abstract

BackgroundProstate cancer among black men is known to have specific molecular characteristics, especially the androgen receptor or enzymes related to the androgen metabolism. These targets are keys to the action of new hormonal therapies. Nevertheless, literature has a lack of data regarding black men. We aimed to gather the available literature data on new hormonal therapies among black populations.MethodsWe conducted a literature review from the PubMed / MEDLINE database until October 2020. All clinical studies of new hormonal therapies and black populations, regardless of methodology, were included.ResultsFour studies provided data on new hormonal therapies in black populations. Three studies reported a PSA decline in black patients treated with Abiraterone, higher in black men than in white men. Overall survival also appears to be higher in black patients treated with Abiraterone only or first.ConclusionFew articles have evaluated the effectiveness and safety of use of these treatments among black populations. The first results seem to show that Abiraterone can provide a benefit in overall survival in black populations. Prospective studies are needed to answer these questions in the future.

Highlights

Prostate cancer among black men is known to have specific molecular characteristics [10], especially the androgen receptor (AR) or enzymes related to the androgen metabolism (i.e CYP17)
N = 1191 patients were included in these studies, including 1116 patients for the retrospective cohort by Leuva et al Three studies evaluated abiraterone only, and one abiraterone and/or enzalutamide with mostly abiraterone treated patients
The new hormonal therapies are the reference treatment for prostate cancer, including for black populations, despite molecular specificities interfering with the mechanisms of action of the molecules used (i.e Abiraterone, Enzalutamide, Apatumide and Darolutamide)

Summary

Introduction

Prostate cancer among black men is known to have specific molecular characteristics, especially the androgen receptor or enzymes related to the androgen metabolism These targets are keys to the action of new hormonal therapies. The effect of castration on metastatic PCa by androgen injections has been known since the 1940s [2]. Prostate cancer among black men is known to have specific molecular characteristics [10], especially the androgen receptor (AR) or enzymes related to the androgen metabolism (i.e CYP17).

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