Abstract
The SARS-CoV-2, a novel virus has shown an association with central nervous system (CNS) symptoms. Initial retrospective studies emerging from China and France, as well as case reports from different parts of the world revealed a spectrum of neurological symptoms ranging from a simple headache to more serious encephalitis and dysexecutive syndromes. Authors have tried to explain this neurotropism of the virus by comparing invasion mechanisms with prior epidemic coronavirus like severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). Concrete evidence on those viruses has been limited. This review attempts to discuss various pathophysiological mechanisms as it relates to neurological complications of SARS-CoV-2. We will also discuss the neurological manifestations seen in various retrospective studies, systemic reviews, and case reports.
Highlights
BackgroundThe COVID-19 pandemic has affected people worldwide and poses a severe health threat on a global scale
Initial retrospective studies emerging from China and France, as well as case reports from different parts of the world revealed a spectrum of neurological symptoms ranging from a simple headache to more serious encephalitis and dysexecutive syndromes
Unlike central nervous system (CNS) abnormalities which were accompanied by changes in laboratory studies, there were no significant differences in the laboratory and cerebrospinal fluid (CSF) findings among patients with or without peripheral nervous system (PNS) symptoms [8]
Summary
1. Emergency Medicine, Trinity West Medical Center Msopti Em Program, Steubenville, USA 2. Miscellaneous, Mayo Clinic Alix School of Medicine, Rochester, USA 3. Internal Medicine, Texas A&M Health Science Center, Bryan, USA 5. Internal Medicine, University of North Texas, Dallas, USA
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