Abstract
Background Mitochondrial respiratory chain is the major site to produce reactive oxygen species (ROS) when myocardium suffers from ischemia/reperfusion injury.As a main component of mitochondrial respiratory chain,complex Ⅲ completes electron transfer and oxidative phosphorylation with other complexes.As recent researches show,complex Ⅲ has taken an important role in myocardial protection when preconditioning.Objective The review,based on the summary of the recent-year studies and researches,elaborates myocardial protection of complex Ⅲ and its mechanism in preconditioning.Content Complex Ⅲ is the major site to produce ROS in preconditioning.Such mechanisms as raising the mitochondrial membrane potential (m△Ψ) and changing the activity of complex Ⅲ,etc,can mediate complex Ⅲ to produce the ROS myocardial protection signaling molecule in preconditioning,thus protecting myocardium.Trend Explorations in the future researches will be on the mechanism of the regulation of the complex Ⅲ to produce the ROS signal in preconditioning,and meanwhile strengthening the clinical application of complex Ⅲ to produce ROS for the myocardial protection in preconditioning,which will provide strong method for clinical myocardial protection. Key words: Complex Ⅲ ; Preconditioning; Reactive oxygen species; Myocardial
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Anesthesiology and Resuscitation
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
