A Review of Magnetically Recyclable Nanocatalysts for the Synthesis of Quinazoline and its Derivatives

Abstract

Abstract: The utility of quinazoline scaffolds as intermediates in new medicinal drug development and discovery has grown in recent decades. The quinazoline framework is a valuable pharmacophore, intermediate, and interesting building block with a wide range of pharmacological activities that has piqued the interest of researchers in developing novel synthetic strategies in medicinal chemistry. In contrast to time-, solvent-, and energy-consuming separation approaches, magnetic separation is an effective method for the quick separation of catalysts from reaction media. Nowadays, magnetically separable nanoparticles have recently gained much interest from chemist in recent research due to their remarkable catalytic activity in various chemical transformations. Many research articles have been published for the synthesis of quinazoline derivatives based on utilizing nanoparticles as a catalyst because of the significant role that biological quinazoline plays in medicinal chemistry. In the present review study, we summarize the surface functionalization of mesoporous silica, metal organocatalysts, ionic liquids, and polymer-supported magnetic nanoparticles and their applications as magnetically recoverable nanocatalysts in the efficient synthetic methods of biologically active quinazoline and its derivatives.