Abstract
The two major topics concerning the development of nanomedicine are drug delivery and tissue engineering. With the advance in nanotechnology, scientists and engineers now have the ability to fabricate functional drug carriers and/or biomaterials that deliver and release drugs locally as well as promote tissue regeneration. In this short review, we address the use of nanotechnology in the fabrication of biomaterials (i.e., nanoparticles and nanofibers) and their therapeutic function in wound healing as dressing materials. Furthermore, we discuss the use of surface nanofeatures to regulate cell adhesion, migration, proliferation, and differentiation, which is a crucial step in wound healing associated with tissue regeneration. Given that nanotechnology-based biomaterials exhibit superior pharmaceutical performance as compared to the traditional medicine, this short review provides current status and future directions of how nanotechnology is and will be used in biomedical field, especially in wound healing.
Highlights
Recent development in nanotechnology facilitates the advance of biomaterials in their structure-property-function relationships
Fibers are considered as twodimensional biomaterials where the high surface area and the porous structure provide excellent therapeutic efficacy in drug release. These nanotechnology-based biomaterials have the potential in promoting cell interaction with the drug carrier and making them ideal candidates in drug delivery applications
At 3 wt% curcumin loading, results showed that PCL/gum tragacanth (GT)/Cur nanofibers released 65% of the drug after 20 days, whereas wound closure rates in a mouse model significantly improved with the use of PCL/GT/Cur dressings, including those preseeded with mesenchymal stem cells on the nanofibers
Summary
Recent development in nanotechnology facilitates the advance of biomaterials in their structure-property-function relationships. Nanoparticles have been used for drug delivery vehicles in many disease states These onedimensional biomaterials are often made from natural or synthetic polymers that are biodegradable so that the encapsulated drug can be programmed for a particular release rate. Fibers are considered as twodimensional biomaterials where the high surface area and the porous structure provide excellent therapeutic efficacy in drug release These nanotechnology-based biomaterials have the potential in promoting cell interaction with the drug carrier and making them ideal candidates in drug delivery applications. Having the ability of using nanotechnology to control the surface features and/or properties is an important topic in the field of tissue engineering In this short review, we discuss nanotechnology-based biomaterials in the form of nanoparticles, nanofibers, and surface nanofeatures on the impact of wound healing. Journal of Nanotechnology of biomaterials, how these functional materials promotes wound healing, and future directions of using nanotechnology in fabrication of biomaterials to achieve desire therapeutic functions
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