A review of draft Environmental Protection Agency Method 1633: A data user's perspective

Abstract

AbstractCurrently, the availability of multilaboratory‐validated analytical methods for per‐ and polyfluoroalkyl substances (PFAS) is limited. Two of the more commonly known methods are the finalized United States Environmental Protection Agency (EPA) methods for the analysis of select PFAS in drinking water samples, EPA 537.1, Determination of Selected Per‐ and Polyfluorinated Alkyl Substances in Drinking Water by Solid Phase Extraction and Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS) (EPA 600‐R‐20‐006) and EPA 533, Determination of Per‐ And Polyfluoroalkyl Substances in Drinking Water by Isotope Dilution Anion Exchange Solid Phase Extraction and Liquid Chromatography/Tandem Mass Spectrometry (EPA 815‐B‐19‐020) These two methods were developed specifically for drinking water samples, which generally do not have matrix interferences and are generally an easier matrix to analyze. EPA also finalized SW‐846 Method 8327, Per‐ and Polyfluoroalkyl Substances (PFAS) by Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS), which covers the analysis of select PFAS in nonpotable water matrices. However, one of the critical deficiencies in this method is the lack of the gold standard for quantitation, isotope dilution, which has become a critical necessity for the analysis of PFAS in nondrinking water matrices to accommodate for potential matrix interferences. In addition, the United States Department of Defense (DoD) Environmental Data Quality Workgroup (EDQW) has stated that SW‐846 Method 8327 should only be used as a screening method and should not be used for the collection of definitive data. The release of Draft EPA Method 1633, Analysis of Per‐and Polyfluoroalkyl Substances (PFAS) in Aqueous, Solid, Biosolids, and Tissue Samples by LC‐MS/MS (EPA 821‐D‐21‐001), for nonpotable water matrices, is a first step toward providing the laboratory community with a standardized method that can provide accurate results for PFAS in nonpotable water matrices.