A Review of Detection of Antibiotic Residues in Food by Surface-Enhanced Raman Spectroscopy.

Jun-Fa Liang,Qiu-Xiong Ye,Yun-Ting Yi,Gui-Yun Chen,Bin-Bin Zhang,Jia-Jian Lin,Xuncai Chen,Qizhi Luo,Cheng Peng,Zi-Sheng Yao,Yu Wang,Peiyu Li,Demetrio Milea

doi:10.1155/2021/8180154

Abstract

Antibiotics, as veterinary drugs, have made extremely important contributions to disease prevention and treatment in the animal breeding industry. However, the accumulation of antibiotics in animal food due to their overuse during animal feeding is a frequent occurrence, which in turn would cause serious harm to public health when they are consumed by humans. Antibiotic residues in food have become one of the central issues in global food safety. As a safety measure, rapid and effective analytical approaches for detecting these residues must be implemented to prevent contaminated products from reaching the consumers. Traditional analytical methods, such as liquid chromatography, liquid chromatography mass spectrometry, and capillary electrophoresis, involve time-consuming sample preparation and complicated operation and require expensive instrumentation. By comparison, surface-enhanced Raman spectroscopy (SERS) has excellent sensitivity and remarkably enhanced target recognition. Thus, SERS has become a promising alternative analytical method for detecting antibiotic residues, as it can provide an ultrasensitive fingerprint spectrum for the rapid and noninvasive detection of trace analytes. In this study, we comprehensively review the recent progress and advances that have been achieved in the use of SERS in antibiotic residue detection. We introduce and discuss the basic principles of SERS. We then present the prospects and challenges in the use of SERS in the detection of antibiotics in food. Finally, we summarize and discuss the current problems and future trends in the detection of antibiotics in food.

Highlights

Antibiotics are a class of secondary metabolites or synthetic analogs that can interfere with cell development at low concentrations and kill or inhibit the growth of microorganisms [1]
Since Sir Fleming first discovered that penicillin has antibiotic properties in 1928, various antibiotics have been developed and used to prevent and treat human diseases. ey have been widely used in the prevention and treatment of diseases in the animal breeding industry to increase productivity
Surface-enhanced Raman spectroscopy (SERS) is a surfacesensitive technique that enhances Raman scattering by molecules adsorbed on rough metal surfaces

Summary

Introduction

Antibiotics are a class of secondary metabolites or synthetic analogs that can interfere with cell development at low concentrations and kill or inhibit the growth of microorganisms (bacteria, archaea, viruses, protozoa, microalgae, and fungi) [1]. Surface-enhanced Raman spectroscopy (SERS) is a surfacesensitive technique that enhances Raman scattering by molecules adsorbed on rough metal surfaces It has been recently developed and applied in antibiotic detection. With the deepening of research involving the use of SERS over the past few decades, various substrates for Raman signal enhancement and different quantitative detection strategies have been developed and used in food safety evaluation [16]. Most of the previous works focused on pesticide residues [17] and environmental testing [18], and studies on antibiotic detection in food using SERS are few.

Theoretical Basis of SERS

Detection of Trace Amounts of Antibiotics in Food via SERS

Findings

Future Trends