A review of compounds derivatives with antimicrobial activities

Abstract

Antimicrobial resistance represents a serious threat to human health across the globe. The cost of bringing a new antibiotic from discovery to market is high and return on investment is low. Furthermore, the development of new antibiotics has slowed dramatically since the 1950s’ golden age of discovery. Medicinal compounds synthesis produce a variety of bioactive compounds that could be used to build a new way for the future discovery pipeline. While many studies have focused on specific aspects of synthetic compounds with antibacterial properties, a comprehensive review of the antibacterial potential of compounds has never before been attempted. This review aims to evaluate reports on some derivatives with significant antimicrobial activities.