Abstract
Summary Calcitonin is a 32 amino acid peptide hormone which regulates calcium homeostasis in vertebrates. It also has analgesic properties, primarily through receptor mediated modulation of serotonergic pain pathways in the central nervous system. Salmon calcitonin has greater physiological and analgesic potency than mammalian forms of the hormone and is therefore reproduced as a synthetic drug for clinical use. A meta-analysis concluded that calcitonin was effective in the treatment of complex regional pain syndrome and systematic reviews reported benefit in the treatment of acute vertebral fracture pain. A randomized controlled trial (RCT) showed calcitonin was effective in the treatment of acute phantom limb pain, however a Cochrane review did not support its use in the treatment of metastatic bone pain although individual RCTs suggested benefit.
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