Abstract
Bunyamwera (BUNV), Batai (BATV), and Ngari (NRIV) are mosquito-borne viruses of the Bunyamwera serogroup in the Orthobunyavirus genus of the Bunyaviridae family. These three viruses have been found to cause disease in both livestock animals, avian species, and humans. Thus, these viruses pose a potential threat to human public health, animal health, and food security. This is especially the case in the developing nations, where BUNV and NRIV are found, mainly in Africa. BUNV and BATV are fairly well characterized, while NRIV is not well characterized owing to only sporadic detection in human and animal populations in Africa. Reassortment is common among bunyaviruses, but NRIV is believed to be the only natural reassortant of the Bunyamwera serogroup. It resulted from a combination of BUNV S and L segments and the BATV M segment. This indicates at least some level co-circulation of BUNV and BATV, which have no historically been reported to overlap in geographic distributions. But as these viruses are undercharacterized, there remains a gap in the understanding of how such reassortment could occur, and the consequences of such. Due to their combined wide range of hosts and vectors, geographic distributions, potential severity of associated diseases, and potential for transmissibility between vertebrate hosts, these viruses represent a significant gap in knowledge with important One Health implications. The goal of this review is to report available knowledge of and identify potential future directions for study of these viruses. As these are collectively understudied viruses, there is a relative paucity of data; however, we use available studies to discuss different perspectives in an effort to promote a better understanding of these three viruses and the public and One Health threat(s) they may pose.
Highlights
Bunyamwera virus (BUNV), Batai virus (BATV), and Ngari virus (NRIV) are members of the Bunyamwera serogroup in the Orthobunyavirus genus of the Bunyaviridae family [1,2,3,4,5]
Reassortments are relatively common among Bunyaviridae family members and even within the Orthobunyavirus genus, but NRIV is the only naturally occurring reassortment in the Bunyamwera serogroup, though experimental reassortants have been derived [1, 7,8,9,10]
Evidence suggests that NRIV arose from a natural reassortment event resulting from co-infection of BUNV and BATV, as NRIV possesses the M segment of BATV combined with the S and L segments from BUNV [1, 3, 11]
Summary
Bunyamwera virus (BUNV), Batai virus (BATV), and Ngari virus (NRIV) are members of the Bunyamwera serogroup in the Orthobunyavirus genus of the Bunyaviridae family [1,2,3,4,5]. They are thought to be primarily transmitted by mosquitoes. Reassortments are relatively common among Bunyaviridae family members and even within the Orthobunyavirus genus, but NRIV is the only naturally occurring reassortment in the Bunyamwera serogroup, though experimental reassortants have been derived [1, 7,8,9,10]. Evidence suggests that NRIV arose from a natural reassortment event resulting from co-infection of BUNV and BATV, as NRIV possesses the M segment of BATV combined with the S and L segments from BUNV [1, 3, 11]
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