A REVIEW OF ANTIOXIDANT ENZYMES, OXIDATIVE STRESS, LIPID PROFILE AND LIPOPROTEIN CONSTITUENTS IN THE PATIENTS OF CORONARY ARTERY DISEASE (CAD) WITH TYPE 2 DIABETES MELLITUS (T2DM)

Abstract

Hyperglycemia, oxidative stress and dyslipoproteinemia are well known factors for Coronary artery disease (CAD) which is the major cause of mortality and morbidity worldwide. The incident of CAD with type 2 diabetes mellitus (T2DM) is rising and they are predicted to be the biggest cause of death by 2020 in India. Therefore, the aim of the present study was to assess the association of hyperglycemia, oxidative stress, antioxidant enzymes, lipid profile and lipoprotein sub fractions in CAD with T2DM patients as well as to compare the results with age-sex matched healthy human volunteers. Three hundred participants were enrolled for the present study, with their ages ranging from 45 to 55 years from Era’s Lucknow Medical College & Hospital, Lucknow. Out of which one hundred fifty were clinically new diagnosed case of CAD with T2DM like hyperglycemia, angina pectoris and Myocardial infarction (MI), remaining one hundred fifty were healthy controls. All biochemical assays were carried out by the standard kit methods. These participants were investigated for serum lipid profile, Lipoprotein sub fractions along with blood levels of lipid peroxide, reduced glutathione and antioxidant enzymes. A marked impairment in plasma levels of lipid profile accompanied with increase in the lipids and apo-protein levels of serum β lipoproteins following decrease in lipid and protein constituents of α lipoprotein, reduced glutathione as well as level of antioxidant enzymes were noted in CAD with T2DM patients with respected to healthy controls.