Abstract
Codeine is derived from morphine, an opioid analgesic, and has weaker analgesic and sedative effects than the parent molecule. This weak opioid is commonly used in combination with other drugs for over-the-counter cough relief medication. Due to the psychoactive properties of opioid drugs, the easily obtained codeine often becomes subject to misuse. Codeine misuse has emerged as a concerning public health issue due to its associated adverse effects such as headache, nausea, vomiting, and hemorrhage. Thus, it is very important to develop reliable analytical techniques to detect codeine for both quality control of pharmaceutical formulations and identifying drug misuse in the community. This review aims to provide critical outlooks on analytical methods applicable to the determination of codeine.
Highlights
Codeine (3-methylmorphine) is an alkaloid prepared from the methylation of morphine derived from poppy seeds (Papaver somniferum) [1]
Codeine is an opioid analgesic that is usually available through prescriptions or over the counter in combination with other drugs
Reliable analytical techniques are critical for both quality control of the drug in pharmaceutical dosage forms and the detection of potential misuse by patients
Summary
Rimadani Pratiwi 1, * , Eka Noviana 2 , Rizky Fauziati 1 , Daniel Blascke Carrão 3 , Firas Adinda Gandhi 1 , Mutiara Aini Majid 1 and Febrina Amelia Saputri 1. Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
