Abstract
Nitrogen sulphur containing heterocycles have specific properties due to which they can be used as a potential material in a different type of industries such as medicinal/pharmaceutical, paint, packing and textile, required for various chemical, physical operations and their use as products. Especially dyes, paint, agrochemicals, medicine, etc. make them more significant. In present days, Nitrogen-Sulfur heterocycles are repeatedly attracting the interest of chemists due to their exceptional bioactive behavior. The present study is a review of the work carried out by a chemist in the discovery of new, effective, medicinally important heterocyclic compounds. The present review basically focused on nitrogen-sulfur heterocycles of potential therapeutic interest, especially with thiazole, thiazine, pyrimidine, morpholine and piperazine heterosystems, benzothiazines, pyrazole-benzothiazines, morpholine-benzothiazines, piperazine-benzothiazines and pyrimidine-benzothiazoles, mainly due to their unique structural features, which enable them to exhibit a number of biological and pharmacological activities. Due to a novel mode of action, a broad spectrum of activity, lesser toxicity towards mammalian cells, and suitable profiles towards humans have triggered the use of Nitrogen Sulphur containing heterocycles in designing and synthesizing their derivatives with better properties. The overall objective of the review is to discuss the importance of novel biodynamic structurally diverse heterocycles of potential therapeutic interest: pyrimidine, morpholine, piperazine, pyrozole, benothiazoles, pyrimidobenzothiazoles, 4H-1,4-benzothiazines, pyrazolyl-benzothiazines, morpholinyl-benzothiazines and piperazinylbenzothiazines in order to have access to important commercial molecules for the search of better future.
Highlights
Heterocycles are considered as the largest section of chemistry, especially organic chemistry
Different types of commercially important compounds alkaloids like vinblastine, reserpine, morphine, ellipticine, antibiotics like cephalosporin, penicillin etc., cardiac glycosides and different type of pesticides are heterocycles of meaning for animal and human health
The majority of the important advances have been developed by synthesizing new heterocycles which imitate natural products with similar biological activities
Summary
Heterocycles are considered as the largest section of chemistry, especially organic chemistry. A specific class of heterocycles having sulfur-nitrogen heteroatoms includes very important aromatic compounds that show physicochemical properties with significance in the development of futuristic materials such as magnets and molecular conductors. The nitrogen-sulphur heterocycles exhibit physicochemical properties and reactivity fairly diverse from the precursor carbocyclic compounds [8 12]. We have focused on nitrogen-sulfur heterocycles of potential therapeutic interest especially with thiazole, thiazine, pyrimidine, morpholine and piperazine heterosystems, benzothiazines, pyrazolylbenzothiazines, morpholinylbenzothiazines, piperazinylbenzothiazines and pyrimidobenzothiazoles, mainly due to their unique structural features, which enable them to exhibit a number of biological and pharmacological activities. The pharmacological/biological activities of heterocyclic compounds mainly depend on the structural specificity and the strength of interaction between a drug and receptors present in the biological system
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