Abstract
Basal cell carcinoma (BCC) is a rare nonacinar variant of prostatic carcinoma. In spite of prostatic acinar adenocarcinoma being one of the most common carcinomas in prostate, <100 prostatic BCC cases have been reported to date. Adenoid cystic/cribriform histology has been described in varying proportions to occur in prostatic BCC and is reported to be associated with aggressive behavior and high risk of metastasis. Herein, we present a case of prostatic BCC with adenoid cystic morphology, comprehensively describe its immunohistochemical and MYB/MYBL1 gene rearrangement findings, discuss its differential diagnosis, and review the literature of this rare entity.
Highlights
Basal cell carcinoma (BCC) is a rare malignant neoplasm of the prostate that is composed of prostate basal cells [1]
Prostatic BCC was initially referred to as adenoid cyst carcinoma (ACC) of the prostate due to the presence of cribriform pattern with intraluminal eosinophilic hyalinized substance and its resemblance to the salivary gland and breast counterparts [1]
We report a rare case of prostatic BCC and discuss the differential diagnosis and immunohistochemical profile that can help establish the correct diagnosis
Summary
Basal cell carcinoma (BCC) is a rare malignant neoplasm of the prostate that is composed of prostate basal cells [1]. Prostatic BCC was initially referred to as adenoid cyst carcinoma (ACC) of the prostate due to the presence of cribriform pattern with intraluminal eosinophilic hyalinized substance and its resemblance to the salivary gland and breast counterparts [1]. Prostatic BCC without cribriform morphology can have overlapping features to a spectrum of benign entities in the prostate, such as florid basal cell hyperplasia [15]. For such morphologically challenging cases, immunohistochemical (IHC) stains including Bcl-2 and Ki-67 can aid in the diagnosis [16]. Translocation, resulting in a fusion of MYB oncogene to the transcription factor gene NFIB, has been observed in a subset of prostatic BCC with ACC morphology [4]. We presented an unusual case of prostatic BCC with mixed ACC and non-ACC histologies and present its immunohistochemical profile and MYB rearrangement findings
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