Abstract
There are many synthesized compounds that contain the five-membered aromatic ring 1,3,4-oxadiazole. It is advantageous for 1,3,4-oxadiazole derivatives to have effective binding with various enzymes and receptors in biological systems through numerous weak interactions, eliciting a variety of bioactivities. This is made possible by the peculiar structural feature of the 1,3,4-oxadiazole ring with pyridine type of nitrogen atom. For scientists, research on the creation of derivatives based on 1,3,4-oxadiazole has become an intriguing subject. Numerous 1,3,4-oxadiazole-based compounds with strong therapeutic potencies are widely utilized to treat a variety of illnesses, which has a significant positive impact on development. In the entire spectrum of medicinal chemistry, including anticancer, antifungal, antibacterial, antitubercular, anti-inflammatory, antineuropathic, antihypertensive, antihistaminic, antiparasitic, antiobesity, antiviral, and other therapeutic agents, this work provides a systematic and thorough review. It is anticipated that this evaluation will be very beneficial for fresh ideas in the search for logical designs for the creation of more effective and less harmful 1,3,4-oxadiazole-based pharmaceutical medicines.
 Keywords: 1,3,4-oxadiazole; anticancer; antimicrobial; antioxidant; isoforms; therapeutic worth.
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