Abstract
In December 2019, a novel coronavirus (COVID-19) unleashed an unprecedented and unanticipated pandemic, causing widespread concern. More than three million deaths have been documented since the first incidence of COVID-19 discovered in China. Several arduous efforts have been made by the governments of various countries worldwide to prevent and control the SARS-CoV-2 infection. This review article discusses an update on all kinds of therapeutic interventions currently applied or developed to treat SARS-CoV-2 condition, including the repurposing of drugs such as Remdesivir, Favipiravir, Ivermectin, etc. We also discuss CRISPR’s potential involvement in antiviral therapy, convalescent plasma therapy, and immunomodulators in combination to tackle the cytokine storms and present a comprehensive overview on many vaccines that have been created to date or are under trials, as well as their platforms and efficacy. Moreover, this article also discusses the mechanism of action of every therapeutic intervention.
Highlights
SARS-CoV-2, referred to as severe acute respiratory syndrome corona virus-2, was first detected in Wuhan city, Hubei province, China, and it has since caused a worldwide pandemic
At the beginning (December 2019), pneumonia of unknown cause was detected, later, it was classified as novel severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) causing COVID-19
This review article first briefly describes the lifecycle of SARS-CoV-2, focuses on covering the powerful drugs and in-hand therapeutic options and potential strategies which have been developed or are in development to fight against COVID-19
Summary
SARS-CoV-2, referred to as severe acute respiratory syndrome corona virus-2, was first detected in Wuhan city, Hubei province, China, and it has since caused a worldwide pandemic. At the beginning (December 2019), pneumonia of unknown cause was detected, later, it was classified as novel severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) causing COVID-19. SARS-CoV-2 is a zoonotic diseasecausing enveloped virus, having a linear single-stranded positive-sense RNA genome of about 30kb in size It has originated in animals but can cause respiratory diseases in humans [2]. Symptoms associated with COVID-19 disease induced by SARS-CoV-2 infection in humans vary from asymptomatic or mild to severely ill. They may arise within two days to two weeks post-exposure to the virus. This review article first briefly describes the lifecycle of SARS-CoV-2, focuses on covering the powerful drugs and in-hand therapeutic options and potential strategies which have been developed or are in development to fight against COVID-19
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