A Review Article on Migrane

Abstract

Migrane are a neurological disorder characterized by recurrent, moderate to severe headache. They are often accompanied by symptoms such as nausea, vomiting, sensitivity to light and sound and in some cases, visual disturbances migraines can significantly impact a person’s quality of life and may require a combination of lifestyles changes, medication and other therapies for effective management. Migraine is the sixth most prevalent disease globally, a major cause of disability, and it imposes an enormous personal and socio-economic burden. Migraine treatment is often limited by insufficient therapy response, leading to the need for individually adjusted treatment. In this review, we analyse historical and current pharmaceutical development approaches in acute and chronic migraine based on comprehensive and systematic analysis of Food and Drug Administration (FDA)-approved drugs and those under investigation. The development of migraine therapeutics has significantly intensified during the last 3 years, as shown by our analysis of the trends of drug development between 1970 and 2020. The spectrum of drug targets has expanded considerably, which has been accompanied by an increase in the number of specialised clinical trials. This review highlights the mechanistic implications of FDA approved and currently investigated drugs and discusses current and future therapeutic options based on identified drug classes of interest.