Abstract
A drug delivery system is a system in which a drug is released from a pharmaceutical dosage form to achieve the desired pharmacological effect. The system consists of conventional and new drug delivery systems. In the new drug delivery system, polymers are used as a matrix. The aim of this article is to find out and understand the formulation and evaluation of natural ingredients that have anticancer activity with different dosage forms and the basis for developing these dosages. Journal searches in this review came from primary data sources on the internet. Journal searches were carried out using a search engine such as Google Scholar, PubMed, and ScienceDirect. In recent years, natural products, such as extract, fraction, and isolate, are getting attention to help treat cancer. Because of their low solubility and bioavailability, the effectiveness tends to be lower than synthetic drugs. Therefore, a dosage form with a new drug delivery system was made to overcome the problem. The dosage forms commonly made are patch, suspension, powder, and emulsion with a new drug delivery system. To ensure the product that has been made met the requirements, they need to be evaluated with various methods like In vitro Study, morphology study, particle size study, and others. Cancer treatment using the natural product can be delivered through several dosage forms like patch, suspension, powder, and emulsion, with specific formulation and manufacturing methods based on several considerations such as natural ingredients properties, dosage form selection, excipient properties, and the purpose of the formulation. Dosage forms that has been made are then evaluated using several evaluation methods.
Highlights
Drug delivery is a method or process of administering a drug compound to achieve a therapeutic concentration so as to produce the desired therapeutic effect on humans or animals [1]
A drug delivery system (DDS) is defined as a formulation or device that enables a therapeutic compound or drug to selectively reach its specific site of action without affecting normal or non-target tissues or cells [2]
In the patch dosage formulation, the polymer is used as a matrix
Summary
Drug delivery is a method or process of administering a drug compound to achieve a therapeutic concentration so as to produce the desired therapeutic effect on humans or animals [1]. Natural ingredients have an important role in the discovery of new drugs, especially for the treatment of cancer and infectious diseases [3]. Natural ingredients, such as extracts, fractions, or isolates, have special characteristics compared to synthetic compounds. For natural ingredients to be made into certain dosage forms needed to be adjusted so that the drug can achieve their target effect. That dosage form and manufacturing method selection are crucial processes in developing a new natural product drug. Natural products with anti-cancer activity have lower side effect compared to synthetic anticancer drugs. Researches regarding anticancer natural product drug are rapidly developing
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