A review and overview of the neuroimaging-genetics features of auditory verbal hallucinations among different mental disorders based on treatment target pattern recognition

Abstract

Auditory verbal hallucinations (AVHs) are defined as the patients experience of the existence of related to themselves when they were in an environment with the absence of external real stimulus and they are suffering from these voice . AVHs individuals are usually accompanied with higher disability and mortality compared to general populations. AVHs can be observed among variety of mental disorders, which subsequently cause misdiagnosis or mistreatment of diseases. Hence, it has become an urgently scientific issue to explore the pathological features and precise therapeutic targets of AVHs. Using high-throughput sequencing-based genomics technology and brain image-based brain connectome technology, we try to explore the imaging-genetic characteristics of six categories of patients with schizophrenia, bipolar disorder, unipolar depression, borderline personality disorder, and healthy individuals with AVHs symptoms. Based on these characteristics, the early qualitative diagnosis and prediction index system of AVHs of different diseases will be helpful to study the mechanism of AVHs. The future direction should focus on revealing the common and specific imaging-genetics features in different diseases from three perspectives: endogenous-genetic, endo-phenotypice (neural-circuit/brain network)-phenotypic characteristics (clinical symptoms). This can help us to explore the precise therapeutic targets of AVHs for different diseases and establish early diagnosis and treatment prediction model. These early prediction model can provide objective information to help the clinicians make precise treatment strategies for different diseases, thereby improving treatment outcomes of these dieseses. Key words: Auditory verbal hallucinations; Psychiatric-neuroimaging-genetics; Neural-circuit; Mental disorder