Abstract
The binding of erythromycin to Escherichia coli ribosomes is apparently dependent upon the incubation temperature and upon the concentration of K + or NH 4 + in the medium. To study the role of these monovalent cations, E. coli ribosomes were pre-incubated at different temperatures in a medium rich or deficient in these cations and the effect of this pre-incubation on the binding ability of the ribosomes was examined. The results suggest that E. coli ribosomes have a conformation favorable for the binding of an erythromycin molecule at sufficient concentrations of K + or NH 4 +, but that the conformation becomes unfavorable for such binding with a decrease in the concentration of K + or NH 4 +, and that the rate of this reversible conversion depends upon the incubation temperature.
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