Abstract
Cancer Signaling proteins in the semaphorin family guide cell migration. Transmembrane semaphorins can act both as ligands (the so-called “forward” signaling pathway) and as receptors (the “reverse” signaling pathway). Gurrapu et al. found that semaphorin 4C (Sema4C) acted as a receptor to promote metastasis by activating transforming growth factor–β signaling in invasive breast cancer cell lines. Overexpression of Sema4C in breast or prostate cancer cells resulted in increased numbers of metastatic colonies in mice. High levels of Sema4C in primary breast tumors correlated with increased metastasis in patients. Sci. Signal. 12 , eaav2041 (2019).
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