Abstract
Onychomycosis in the toenail is a common fungal infection. Moderate to severe onychomycosis, especially, may persist chronically with a considerable recurrence rate that can be a challenge for management. Oral antifungal therapy is the current gold standard to treat for moderate to severe toenail onychomycosis. However, there are alternative combination modalities including topical agents and/or procedural modalities that are emerging because of potential adverse effects of oral antifungals and to prevent recurrence. In this study, oral terbinafine with debridement combination therapy had the shortest washout time. Factors that were related to longer washout times were female sex, extreme body mass index, and diabetes.
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