Abstract
Aim: This study was designed to look at the unique clinical profile, neuro-imaging features and functional outcomes, of Intra-cranial dissections in the cerebral vasculature, seen at two tertiary stroke care centers in Southern India. Materials and Methods: In this retrospectivce study spanning five years (Dec 13 to Dec 18), a total of 496 patients underwent CT Brain with Angiography for evaluation of an Acute stroke syndrome/ Transient ischemic attack (TIA), at our two study centers. 21/496 (4.2%) of these patients had imaging evidence of intra-cranial dissections which was further confirmed by Contrst MR angiograpgy. The clinical and imaging data of these cases was recorded on a predesigned stroke proforma. The pattern of vessel involved and morphology of vessel dissection was analyzed as per standard radiology criteria. All cases had follow up data ranging from 1 to 3 years, which was used to classify the functional outcomes based on the modified Rankin Scale (mRS). Results: There were 15 males and 6 females in the study, and the mean age was 44.1 years (range 23 to 73 years). Focal neurological deficits, with or without raised intra cranial pressure symptoms occurred in all these patients. 10/21 (48%) dissections were in the anterior circulation, whereas 11/21 (52%) were in the posterior circulation. Subarachnoid or parenchymal hemorrhage at presentation was seen in 11/21 (52%). The Internal Carotid artery (C2-C4 segments) was the commonest vessel involved in the anterior circulation in 64% cases (7/11), while in the posterior circulation, Vertebral artery (V4 segment) was most frequently involved in 60% (6/10) cases. In the entire study cohort, a good functional outcome (mRS 1-2) was seen in 13/21 (62%) cases, and death (mRS-5) was seen in 2/21 (9.5%). Digital Subtraction Angiography (DSA) and stenting/coiling procedures were undertaken in 3/21 (14%) cases. Conclusion: This hospital based study brings out the unique clinical spectrum of intra-c
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