Abstract
BackgroundTo retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST).MethodsData from 32 MOGCT (6 dysgerminomas, 6 yolk sac tumors, 17 immature teratomas, and 3 mixed germ cell tumors) and 9 SCST (4 granulosa cell tumors and 5 sertoli-leydig cell tumors) aged from 18 to 35, treated in the Obstetrics and Gynecology Hospital of Fudan University from October 2003 to October 2013 were collected and analyzed.ResultsAverage follow up was (86.3 ± 34.4) months. Average diagnosed age was (25.3 ± 3.5) years. Average chemotherapy course was (4.4 ± 1.3) times. Patients are all living. Thirty one patients (75.6%) reported normal menstrual cycles. Twelve patients (29.3%) wished to conceive, 10 (83.3%) naturally conceived and 8 (66.7%) had lived birth.ConclusionsReproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in MOGCT and SCST are favorable, meanwhile education and consultation is needed.
Highlights
To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST)
MOGCT and SCST are generally occurred in young women, considered low-grade, sensitive to chemotherapy, and good prognosis [2,3,4]
Thirty two MOGCT and 9 SCST patients conducted fertility-sparing surgery and adjuvant chemotherapy with complete follow up data, younger than 35 years old at first treatment, continuously disease-free with minimum follow-up of 2 years in the Obstetrics and Gynecology Hospital of Fudan University from October 2003 to October 2013 were retrospectively investigated
Summary
To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST). Malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST) are not common. Dysgerminoma is the most common histology of MOGCT, followed by immature teratoma and endodermal sinus tumor. SCSTs develop from the gonadal non-germ-cell components [1], including granulosa cell tumors, granulosa-theca tumors, and Sertoli-Leydig cell tumors. MOGCT and SCST are generally occurred in young women, considered low-grade, sensitive to chemotherapy, and good prognosis [2,3,4].
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