Abstract
Leukocyte apheresis is a therapeutic option for moderate-to-severe active ulcerative colitis in Japan. It causes fewer complications, however, leukocyte apheresis requires the use of a relatively large caliber of peripheral venous line for hemodialysis. We reluctantly used a large caliber catheter with a double-lumen into the central vein.
Highlights
Ulcerative colitis (UC) is an idiopathic colonic inflammatory disease
It is important to select as small a caliber of catheter as possible to prevent thrombosis, when we place a central vein catheter in patients in the active phase of ulcerative colitis, as caliber of catheter is associated with thrombus formation
The infiltration of leukocytes into the intestinal mucosa plays an important role in the formation of mucosal lesions via the increased production of cytokines and inflammatory mediators [2]
Summary
Ulcerative colitis (UC) is an idiopathic colonic inflammatory disease. In addition to corticosteroids, 5-aminosalicylic acid and conventional immunosuppressive agents, more recent effective drugs such as infliximab, adalimumab, and tacrolimus, have been introduced to the remission induction therapy of UC. Leukocyte apheresis (LA) is a therapeutic option for steroid-dependent or steroid-resistant UC patients with moderate-to-severe active steroid UC as described in ‘Guidelines for the Management of Ulcerative Colitis in Japan’ [1]. It has fewer complications compared to other drug therapies It does not require the measurement of blood concentrations. Leukocyte apheresis is a therapeutic option for moderate-to-severe active ulcerative colitis in Japan. It causes fewer complications, leukocyte apheresis requires the use of a relatively large caliber of peripheral venous line for hemodialysis. The impact of the catheter size and the thrombosis complication has been not fully elucidated This was a retrospective study of 15 ulcerative colitis patients using the central vein catheters for the leukocyte apheresis
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