A Retrospective Study of Adult Patients with Parry Romberg Syndrome.

Abstract

Parry Romberg Syndrome (PRS), also known as progressive hemifacial atrophy, is characterized by atrophy of skin and subcutaneous tissue, which can include muscle, bone, and cartilage. PRS is a clinical diagnosis, although supportive imaging and/or histology may be obtained. We present a case series of 10 adult patients with a diagnosis of PRS seen at Massachusetts General Hospital and Brigham and Women’s Hospital from 2000 to 2021. Nine out of 10 patients were female, with an average age of onset of 27.3 years and an average of 12.4 years between onset and diagnosis. Of the 10 patients, 4 had biopsies with supportive histopathology findings, and 7 had positive imaging findings. Patients typically received both medical and surgical treatments.