A retrospective study evaluating outcomes of surgical excision versus radiologic follow-up of benign breast papillomas without atypia

Abstract

BackgroundThere is uncertainty whether benign breast papillomas without atypia (BP) can be followed by imaging or require surgical resection. MethodsA single-center, retrospective cohort study of patients diagnosed with BP (2011–2021) to determine the upgrade rate on surgery, and factors associated with surgical intervention and upgrade. Results139 BPs were included. 27(19.4%) had upfront surgery; 112(80.6%) had imaging follow-up. The upfront surgery group had higher rates of pre-excision nipple inversion (n = 2(8.3%)vs.n = 0(0%),p = 0.003). In the imaging group, the median follow-up was 3.8years, and 9 had subsequent resection. Upgrade rate was 5.8%(8/139). Of all BPs undergoing surgery (n = 36), patients ≥60years (75.0%vs.25.0%,p = 0.049) or with family history of breast cancer (87.5%vs.48.1%,p = 0.048) were more likely to have upgrade. ConclusionsDespite a low number of events, this study supports radiologic follow-up of BP except in patients ≥60 years or with family history of breast cancer, adding to the growing body of evidence supporting watchful waiting of BPs.