A Retrospective, Single Institution Study Comparing 5-Fluorouracil, Hydroxyurea, and Twice-Daily Radiation Therapy (FHX) to High-Dose Cisplatin + Radiation Therapy (CRT) in Advanced T Stage Head-and-Neck Squamous Cell Carcinoma (ATSHNSCC): Definitive Management of Head-and-Neck Squamous Cell Carcinoma

Abstract

The current standard approach to ATSHNSCC includes definitive radiation therapy together with concurrent chemotherapy. While FHX has shown promising results in phase 2 studies, direct comparisons to CRT are lacking. At our institution from 1998-2003 the chemoradiation therapy regimen employed was FHX, while that from 2004-2009 was CRT. Therefore, we sought to perform a review of patient outcomes, including overall survival (OS), recurrence rate (RR), and chronic toxicity (CT).